Each organ, says Claude Bernard (27/33. 'Tissus Vivants' 1866 page 22.), has its proper life, its autonomy; it can develop and reproduce itself independently of the adjoining tissues. A great German authority, Virchow (27/34. 'Cellular Pathology' translated by Dr. Chance 1860 pages 14, 18, 83, 460.), asserts still more emphatically that each system consists of an "enormous mass of minute centres of action...Every element has its own special action, and even though it derive its stimulus to activity from other parts, yet alone effects the actual performance of duties...Every single epithelial and muscular fibre- cell leads a sort of parasitical existence in relation to the rest of the body...Every single bone-corpuscle really possesses conditions of nutrition peculiar to itself." Each element, as Sir J. Paget remarks, lives its appointed time and then dies, and is replaced after being cast off or absorbed. (27/35. Paget 'Surgical Pathology' volume 1 1853 pages 12-14.) I presume that no physiologist doubts that, for instance, each bone-corpuscle of the finger differs from the corresponding corpuscle in the corresponding joint of the toe; and there can hardly be a doubt that even those on the corresponding sides of the body differ, though almost identical in nature. This near approach to identity is curiously shown in many diseases in which the same exact points on the right and left sides of the body are similarly affected; thus Sir J. Paget (27/36. Ibid page 19.) gives a drawing of a diseased pelvis, in which the bone has grown into a most complicated pattern, but "there is not one spot or line on one side which is not represented, as exactly as it would be in a mirror, on the other."

Many facts support this view of the independent life of each minute element of the body. Virchow insists that a single bone-corpuscle or a single cell in the skin may become diseased. The spur of a cock, after being inserted into the ear of an ox, lived for eight years, and acquired a weight of 396 grammes (nearly fourteen ounces), and the astonishing length of twenty-four centimetres, or about nine inches; so that the head of the ox appeared to bear three horns. (27/37. See Prof. Mantegazza's interesting work 'Degli innesti Animali' etc. Milano 1865 page 51 tab. 3.) The tail of a pig has been grafted into the middle of its back, and reacquired sensibility. Dr. Ollier (27/38. 'De la Production Artificielle des Os' page 8.) inserted a piece of periosteum from the bone of a young dog under the skin of a rabbit, and true bone was developed. A multitude of similar facts could be given. The frequent presence of hairs and of perfectly developed teeth, even teeth of the second dentition, in ovarian tumours (27/39. Isidore Geoffroy Saint-Hilaire 'Hist. des Anomalies' tome 2 pages 549, 560, 562; Virchow ibid page 484. Lawson Tait 'The Pathology of Diseases of the Ovaries' 1874 pages 61, 62.), are facts leading to the same conclusion. Mr. Lawson Tait refers to a tumour in which "over 300 teeth were found, resembling in many respects milk-teeth;" and to another tumour, "full of hair which had grown and been shed from one little spot of skin not bigger than the tip of my little finger. The amount of hair in the sac, had it grown from a similarly sized area of the scalp, would have taken almost a lifetime to grow and be shed."

Whether each of the innumerable autonomous elements of the body is a cell or the modified product of a cell, is a more doubtful question, even if so wide a definition be given to the term, as to include cell-like bodies without walls and without nuclei. (27/40. For the most recent classification of cells, see Ernst Hackel 'Generelle Morpholog.' b. 2 1866 s. 275.) The doctrine of omnis cellula e cellula is admitted for plants, and widely prevails with respect to animals. (27/41. Dr. W. Turner 'The Present Aspect of Cellular Pathology' 'Edinburgh Medical Journal' April 1863.) Thus Virchow, the great supporter of the cellular theory, whilst allowing that difficulties exist, maintains that every atom of tissue is derived from cells, and these from pre-existing cells, and these primarily from the egg, which he regards as a great cell.

Charles Darwin

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